Sermorelin

IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

Click here to read the Prep & Injection Guide

Sermorelin

Sermorelin is a synthetic version of growth hormone-releasing hormone (GHRH), which is naturally produced in the hypothalamus and stimulates the pituitary gland to release human growth hormone (HGH). HGH is involved in a number of vital biological processes, including tissue growth and repair, fat burning, muscle building, immune function, libido, and more.

Benefits of Sermorelin

• Boosts energy, reducing lethargy and fatigue
• Helps cells generate ATP
• Increases metabolism
• Builds lean muscle
• Increases muscle strength and tone
• Accelerates post-workout muscle recovery
• Enhances cardiovascular endurance and cellular oxygen uptake
• Reduces adipose fat tissue (especially abdominal fat)
• Improves sleep quality
• Boosts collagen synthesis, improving skin quality and appearance
• Accelerates cellular regeneration
• Increases bone density
• Supports cognitive function through healthy GH levels

Side Effects

• Injection site reaction (redness, swelling, itching)
• Headaches
• Fluid retention
• Joint pain
• Increased insulin sensitivity

Side effects are usually mild and temporary, typically resolving within the first few weeks of therapy.

Less common but more serious side effects include:

• Dizziness
• Flushing
• Reduced blood pressure

Exercise caution if you are prone to allergies.

Contraindications

Do NOT use Sermorelin if:

• You have cancer
• You have diabetic retinopathy
• You have an acute critical illness
• You are taking glucocorticoids or thyroid medications (consult your doctor)
• You have Prader-Willi syndrome (consult a physician)

RECONSTITUTION, DOSING, & MISCELLANEOUS CONSIDERATIONS

SERMORELIN: 5MG

12-16 week cycle followed by 6-8 week washout

Dose at bedtime

Take dose while fasted (at least 1.5 hours after last meal)

Subcutaneous Administration

RECONSTITUTION

Mix with 2.5mL (250 units) of BAC water

STANDARD PROTOCOL

Weeks 1-4: 10 units (200mcg), 1x/day

Weeks 5-8: 15 units (300mcg), 1x/day

Weeks 9-12: 20 units (400mcg), 1x/day

Weeks 13-16: 25 units (500mcg), 1x/day

MAXIMUM PROTOCOL

Weeks 1-4: 15 units (300mcg), 1x/day

Weeks 5-8: 20 units (400mcg), 1x/day

Weeks 9-12: 25 units (500mcg), 1x/day

Weeks 13-16: 30 units (600mcg), 1xday

SERMORELIN: 10MG

12-16 week cycle followed by 6-8 week washout

Dose at bedtime

Take dose while fasted (at least 1.5 hours after last meal)

Subcutaneous Administration

RECONSTITUTION

Mix with 2.5mL(250) of BAC water

STANDARD PROTOCOL

Weeks 1-4: 5 units (200mcg), 1x/day

Weeks 5-8: 8 units (300mcg), 1x/day

Weeks 9-12: 10 units (400mcg), 1x/day

Weeks 13-16: 13 units (500mcg), 1x/day

MAXIMUM PROTOCOL

Weeks 1-4: 8 units (300mcg), 1x/day

Weeks 5-8: 10 units (400mcg), 1x/day

Weeks 9-12: 13 units (500mcg), 1x/day

Weeks 13-16: 15 units (600mcg), 1xday

Stacking Suggestions

• Ipamorelin – synergistic GH secretagogue that increases growth hormone output without raising cortisol or prolactin
• CJC-1295 (No DAC) – boosts GH pulsatility when paired with Sermorelin
• BPC-157 or TB-500 – accelerate muscle recovery and improve soft tissue repair
• AOD-9604 – promotes fat burning and body recomposition alongside Sermorelin’s anabolic effects
• Glutathione or NAD+ – support mitochondrial health and anti-aging effects during long-term hormone optimization
• L-Arginine or GABA – may further enhance natural GH production when combined with Sermorelin before sleep

Sermorelin + Ipamorelin is one of the most clinically supported stacks for long-term GH optimization.