SS-31

IMPORTANT: Read This Before Proceeding With Dosing
Go to the Prep & Injection Guide for proper reconstitution, syringe sizing, and injection protocols. Mistakes here can compromise your research.

Click here to read the Prep & Injection Guide

SS-31, also known as Elamipretide, Bendavia, or MTP-131, is a synthetic peptide that targets and improves mitochondrial function. Mitochondria generate ATP (the body’s primary energy molecule), regulate cellular homeostasis, and impact nearly all physiological systems. SS-31 is a mitochondrial-targeted antioxidant with extensive therapeutic potential: mitigating oxidative stress, suppressing inflammation, maintaining mitochondrial health, and preventing cellular apoptosis.

It has several advantages over natural antioxidants and plays a key role in treating mitochondrial dysfunction-related disorders.

BENEFITS

• Increased energy (most potent energy-boosting peptide available)
• Neutralizes free radicals and reverses oxidative stress damage
• Anti-aging
• Anti-inflammatory (including neuroinflammation)
• Supports memory and cognition
• Antifibrotic
• Beneficial for kidney disease (activates AMPK pathway)
• Fights insulin resistance
• May prevent or mitigate symptoms of:
  • Cardiovascular disease
  • Neurodegenerative conditions
  • Asthma and COPD
  • Age-related macular degeneration
  • Cancer
  • Barth syndrome
  • Primary mitochondrial myopathy
  • Duchenne muscular dystrophy
  • Friedrich’s ataxia

POSSIBLE SIDE EFFECTS

• Injection site irritation (redness, swelling, and/or itching)
• Gas
• Gastrointestinal upset
• Headache
• Dizziness
• Signs of an allergic reaction include: fast, erratic heartbeat; profuse sweating; shortness of breath; confusion; severe weakness; loss of coordination; stiff muscles and high fever; eye symptoms including blurred vision, tunnel vision, eye pain, swelling of the eyes, seeing halos around lights

CONTRAINDICATIONS

• Do not use if pregnant or breastfeeding
• Do not use if hypersensitive to mitochondrial-targeted compounds

SS-31: RECONSTITUTION, DOSING, AND OTHER CONSIDERATIONS

8-12 week cycle followed by 4-8 week washout period

Daily Dosing

Dose in the A.M.- dosing at a consistent time of day is recommended

Take in a fasted state

Subcutaneous administration

*Unlike most protocols, I assigned dosing protocols appropriate to each vial size, since to attempt to use 10mg vials for even a low-end standard SS-31 protocol would be extremely expensive. So while technically you COULD use 10mg vials for any of the protocols, it makes zero sense to do so.

SS-31: 10MG DOSING PROTOCOLS (Only recommended when running as supportive precedent to MOTS-C cycle)

Mix with 1mL (100 units) of BAC water

Take 10 units, 1x/day, for 10-14 days prior to start of MOTS-C cycle

SS-31: 30MG DOSING PROTOCOLS

LOW DOSE PROTOCOL

Mix with 2mL (200 units) of BAC water

• Week 1: 7 units (1mg), 1x/day, 5 days/week
• Weeks 2–5: 14 units (2mg), 1x/day, 5 days/week
• Weeks 6–8: 21 units (3mg), 1x/day, 3 days/week
• Weeks 9–12: 28 units (4mg), 1x/day, 3 days/week

STANDARD PROTOCOL

Mix with 2mL (200 units) of BAC water

Take 33 units (5mg), 3-7 days per week, for 8-12 weeks

MAXIMUM PROTOCOL

Mix with 2mL (200 units) of BAC water

• Week 1: 10 units (1.5mg), 1x/day, 5 days/week
• Weeks 2–5: 20 units (3mg), 1x/day, 5 days/week
• Weeks 6–8: 30 units (4.5mg), 1x/day, 3 days/week
• Weeks 9–12: 40 units (6mg), 1x/day, 3 days/week

SS-31: 50MG DOSING PROTOCOLS

LOW DOSE PROTOCOL

Mix with 3mL (300 units) of BAC water

• Week 1: 6 units (1mg), 1x/day, 5 days/week
• Weeks 2–5: 12 units (2mg), 1x/day, 5 days/week
• Weeks 6–8: 18 units (3mg), 1x/day, 3 days/week
• Weeks 9–12: 24 units (4mg), 1x/day, 3 days/week

STANDARD PROTOCOL

Mix with 3mL (300 units) of BAC water

Take 30 units (5mg), 3-7 days per week, for 8-12 weeks

MAXIMUM PROTOCOL

Mix with 3mL (300 units) of BAC water

• Week 1: 9 units (1.5mg), 1x/day, 5 days/week
• Weeks 2–5: 18 units (3mg), 1x/day, 5 days/week
• Weeks 6–8: 27 units (4.5mg), 1x/day, 3 days/week
• Weeks 9–12: 36 units (6mg), 1x/day, 3 days/week

Stacking Suggestions

• MOTS-C – run SS-31 before a MOTS-C cycle for maximum mitochondrial optimization. SS-31 primes the mitochondria, MOTS-C boosts cellular adaptation and metabolic health (Follow standard protocol for 10-14 days prior to start of MOTS-C protocol)
• NAD+ – supports ATP production and cellular repair when paired with SS-31
• Glutathione – enhances antioxidant defense and detoxification during oxidative stress repair
• CJC-1295 / Ipamorelin – supports cellular regeneration and recovery alongside mitochondrial repair
• AOD-9604 – assists with fat metabolism during energy-focused SS-31 cycles
• BPC-157 – promotes systemic healing and combats inflammatory stress